没有光环的偶发性偏头痛患者的延迟折扣率增加
Lu Wang1,2,3, Chenyang Dai1,2,3, Manman Gao1,2
1Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Brain and behavior
|February 20, 2024
概括
没有光环的偶发性偏头痛患者表现出增加的冲动性,特别是更高的延迟折扣率. 这与对奖励处理至关重要的大脑区域神经连接的改变有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 心理学 心理学 心理学
背景情况:
- 冲动性和改变的奖励处理在慢性偏头痛和药物过量使用中被注意到.
- 在没有光环的情节性偏头痛 (EMoA) 中的冲动性概况仍然不太清楚.
研究的目的:
- 为了研究EMOA患者的决策冲动性.
- 探索底层的神经机制,特别是休息状态功能连接 (RSFC),与EMOA中的冲动性相关.
主要方法:
- 招募了51名新诊断的EMOA患者和45名健康对照 (HC).
- 利用延迟折扣任务,认知评估和静止状态功能磁共振成像 (fMRI).
- 分析了关键大脑区域和整个大脑之间的RSFC.
主要成果:
- 在EMOA患者中,主观折扣率明显高于HC患者,与偏头痛史相关.
- 在EMOA患者中观察到减少的RSFC在腹状条纹体 (vSTR),腹中前额皮质和皮质内.
- 折扣率和vSTR-occipital RSFC中的异常与三胺使用有关,RSFC对三胺使用和折扣有中介作用.
结论:
- EMoA与延迟折扣的增加有关,这表明冲动性增加.
- 变更的价值处理网络连接,特别是涉及vSTR和occipital区域,是EMOA这种冲动性的基础.
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