在强迫症障碍中,右背侧前额叶皮质在静止状态下功能连接性减少
Zhaoxi Zhong1, Yangpan Ou2, Yunhui Chen3
1Henan Key Laboratory of Biological Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Brain and behavior
|February 20, 2024
概括
右背侧前额皮质 (DLPFC) 的休息状态功能连接 (FC) 在强迫症 (OCD) 中发生变化. 减少右DLPFC-右MTG连接性预测了强迫症患者的治疗反应.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 神经成像研究表明,右背侧前额叶皮质 (DLPFC) 在强迫症神经生物学中存在影响.
- 关于强迫症患者右侧DLPFC的静止状态功能连接 (FC) 模式的研究有限.
研究的目的:
- 在强迫症患者中研究右背侧前额皮层 (DLPFC) 的静止状态功能连接 (FC) 模式.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 对28名没有药物治疗的强迫症患者和20名健康对照进行.
- 基于种子的FC分析和支持向量机 (SVM) 用于分析fMRI数据.
主要成果:
- 与对照人群相比,强迫症患者在右中旋 (MTG),右上旋,右腹前带状皮质 (vACC) 和左Crus II中表现出减少的FC.
- 经过8周的药物治疗,在强迫症患者中没有观察到显著的FC差异.
- 减少了右DLPFC-右MTG和右DLPFC-右vACC连接,与强迫症症状严重程度相关.
- 在休息状态下减少右DLPFC-右MTG连接预测了对强迫症药物的治疗反应.
结论:
- 这些发现强调了右侧DLPFC在强迫症疾病 (OCD) 病理生理学的重要作用.
- 右DLPFC的静止状态FC可以作为强迫症治疗反应的潜在生物标志物.
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