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基于系统性炎症反应指数预测中风后的认知障碍

Min Chu¹, Yunhe Luo¹, Daosheng Wang²

¹Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China.

Brain and behavior

|February 20, 2024

概括

系统性炎症反应指数 (SIRI) 与急性缺血性中风 (AIS) 患者的中风后认知障碍 (PSCI) 有关. 一个新的纳米图集SIRI助力早期识别PSCI风险.

科学领域:

神经学神经学
炎症研究炎症研究
生物标志物发现发现

背景情况:

脑卒中后认知障碍 (PSCI) 是中风幸存者的常见并发症.
系统性炎症反应指数 (SIRI) 是已知的炎症疾病预测指标,但其在PSCI中的作用尚不清楚.

研究的目的:

在急性缺血性中风 (AIS) 患者中调查SIRI和PSCI之间的关联.
开发和验证用于预测AIS患者PSCI风险的诺米克图.

主要方法:

分析了1342名AIS患者的队列.
患者在中风后两周内使用迷你精神状态检查评估PSCI.
使用后勤回归构建了一个名图,并使用ROC,校准曲线和DCA进行验证.

主要成果:

51.4%的患者出现了PSCI.
升高的SIRI是PSCI的一个独立风险因素 (OR=1.226,p<0.001).
开发的诺米图表显示出良好的区分能力 (AUC=0.716) 和临床实用性.

结论:

入院时增加的SIRI与AIS患者的PSCI相关.
纳米图,包括SIRI,为早期PSCI风险识别提供了有价值的工具.

关键词:

急性缺血性中风是急性缺血性中风.这是一种炎症炎症炎症炎症.这个名字是名ogramogram.脑卒中后的认知障碍脑卒中后的认知障碍系统性炎症反应指数

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