乳酸脱酶与发展缺血性中风风险之间的因果关系:孟德尔的随机研究
Fuxiang Dong1, Xu Wang1,2, Jinjian Li1
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Brain and behavior
|February 20, 2024
概括
这项研究调查了乳酸脱酶 (LDH) 与缺血性中风 (IS) 风险之间的因果关系. 门德尔随机化分析揭示了一个反向关联,表明较低的LDH水平可能会降低IS风险,这与之前的观察结果相矛盾.
科学领域:
- 生物医学是生物医学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 缺血性中风 (IS) 是一个重大的全球健康挑战.
- 乳酸脱酶 (LDH) 和IS风险之间的因果关系尚不清楚.
- 调查潜在的因果关系对于理解IS的发病过程至关重要.
研究的目的:
- 确定乳酸脱酶 (LDH) 是否因果影响缺血性中风 (IS) 的风险.
- 使用门德尔的随机化来评估LDH和IS之间的遗传关联.
- 提供支持或反对LDH水平和IS发展之间的因果关系的证据.
主要方法:
- 使用了两个样本的门德尔随机化设计.
- 用于LDH和IS的全基因组关联研究 (GWAS) 数据.
- 选择的单核酸多态 (SNPs) 与LDH作为仪器变量相关.
- 应用了反变量加权 (IVW),MR-Egger和加权中位数分析方法.
主要成果:
- 确定了15个重要的LDHSNP作为仪器变量.
- 在所有应用的方法中观察到LDH和IS风险之间的一致反向关联.
- 在IVW方法表明因果关系 (OR,0.997;95%CI 0.995-0.999).
- MR-Egger和加权中位数方法证实了这些发现,表明LDH对IS的保护作用.
结论:
- 门德尔的随机化分析表明,乳酸脱酶 (LDH) 与缺血性中风 (IS) 风险相反相关.
- 这些发现与之前的观察性研究相矛盾.
- 在IS的发展中,LDH可能起着保护作用.
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