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Updated: May 9, 2026

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综合生物信息学方法解开关键基因和涉及结肠直肠癌的途径

Syeda Anjum Mobeen1, Pallavi Saxena2,3, Arun Kumar Jain2

  • 1Department of Biotechnology and Bioinformatics, Yogi Vemana University, Andhra Pradesh, India.

Journal of cancer research and therapeutics
|February 20, 2024
PubMed
概括

这项研究确定了结直肠癌 (CRC) 发病过程中的关键基因,揭示了ATM,GAPDH,CREB1,VEGFA和CDH1作为CRC的潜在治疗标. 这些发现为CRC分子瘤发生和疾病监测提供了新的见解.

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...