基于癌症干预和监测建模网络估计的乳腺癌查策略的结果
Debra L Monticciolo1, R Edward Hendrick1, Mark A Helvie1
1From the Department of Radiology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756 (D.L.M.); Department of Radiology, University of Colorado School of Medicine, Aurora, Colo (R.E.H.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (M.A.H.).
Radiology
|February 20, 2024
概括
从40岁开始每年进行乳房造影,为乳腺癌查提供了最大的好处. 这种方法可以降低死亡率并增加获得的生命年数,最小的假阳性和良性活检.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 关于乳腺癌查的最佳频率和发病年龄存在争议.
- 乳房扫描查策略旨在早期检测乳腺癌.
研究的目的:
- 用癌症干预和监测建模网络 (CISNET) 的估计来比较乳腺癌查结果.
- 评估各种哺乳镜查情景的好处和风险.
主要方法:
- 假设的美国队列的CISNET建模,比较不同的乳房镜查策略.
- 场景包括两年一次的查 (50-74岁和40-74岁) 和年度查 (40-74岁和40-79岁).
- 终身福利,错误阳性率和良性活检率的比较.
主要成果:
- 与两年一次的查 (25.4%-30%) 相比,每年一次的查 (40-79岁) 显示出优异的乳腺癌死亡率降低 (41.7%).
- 这种情况避免了最多的死亡 (11.5/1000),并获得了最多的生命年 (230/1000).
- 年度查 (40-79岁) 产生了最低的假阳性率 (6.5%) 和良性活检率 (0.88%).
结论:
- 根据CISNET 2023的建模,从40岁开始每年进行乳腺癌查可以获得最大的益处.
- 这种策略提供了最大的降低死亡率和增加寿命.
- 从40岁开始的年度查呈现了每次检查的最低风险.
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