功能性治愈与接受活跃慢性乙型肝炎抗病毒治疗的儿童年龄较小有关
Min Zhang1, Jing Li2, Zhiqiang Xu1
1Department of Liver Diseases, National Clinical Research Center for Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Hepatology international
|February 20, 2024
概括
患有慢性乙型肝炎 (CHB) 的年龄较小的儿童 (1-7岁) 与年龄较大的儿童 (≥7岁) 相比,通过抗病毒治疗实现了更高的功能治愈率. 这些发现支持儿科CHB患者的早期治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 儿童传染病 儿童传染病
背景情况:
- 对于慢性乙型肝炎 (CHB) 的功能治疗仍然是当前抗病毒疗法所面临的挑战.
- 关于患有CHB的儿科患者群体的治疗结果的数据有限.
研究的目的:
- 评估在接受抗病毒治疗的活跃CHB儿童中功能治愈的频率.
- 为了比较儿科CHB患者不同年龄组之间的治疗结果.
主要方法:
- 对372名儿童 (1-16岁) 进行了回顾性研究,这些儿童患有活跃的CHB.
- 治疗包括核胺模拟单疗或与干扰素-α (IFN-α) 联合治疗,持续24-36个月.
- 通过乙型肝炎病毒 (HBV) 的DNA损失,HBeAg损失/血清转化以及HBsAg损失定义的功能治愈.
主要成果:
- 1-7岁儿童的HBVDNA清除率,HBeAg血清转化率和HBsAg损失率明显高于≥7-16岁儿童.
- 年龄较小的儿童 (1-7岁) 在HBVDNA,HBeAg和HBsAg水平下降得更快.
- 较低的基线HBsAg水平 (<1,500 IU/mL) 与改善的治愈率有关;没有报告严重不良事件.
结论:
- 活跃CHB的1-7岁儿童通过抗病毒疗法获得更高的功能治愈率,而不是较大的儿童.
- 这些发现支持在儿科CHB早期启动抗病毒治疗.
- 需要进一步的前性随机对照试验来验证这些结果.
关键词:
抗病毒疗法是一种抗病毒疗法.孩子孩子孩子孩子孩子孩子慢性乙型肝炎 慢性乙型肝炎功能疗法是一种功能疗法.这就是HBV HBV.乙型肝炎病毒的DNA损失在 HBeAg 血清转化过程中.导致HBsAg的损失.干扰素是干扰素的一种.核类型的类似物更多相关视频
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