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瓦索希宾-1表达可以预测病理完整的缓解的晚期膀癌与新辅助化疗

Minami Omura¹, Takeo Kosaka², Hiroaki Kobayashi¹

¹Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Annals of surgical oncology

|February 20, 2024

概括

高密度的瓦索希宾-1 (VASH1) 预测了膀癌 (BCa) 中更好的化疗反应. 这一发现可能有助于确定从新辅助化疗 (NAC) 中获益最多的患者.

科学领域:

在瘤学瘤学.
癌症生物标志物癌症生物标志物
血管新生的产生.

背景情况:

新辅助化疗 (NAC) 是侵入性膀癌 (BCa) 的标准,但患者的选择是困难的.
血管新生调节剂Vasohibin-1 (VASH1) 在晚期BCa中升高,但其在化疗反应中的作用尚不清楚.

研究的目的:

调查VASH1作为预测BCa.中NAC反应的潜在生物标志物.
探索血管生成,缺氧和化疗结果之间的关系.

主要方法:

在接受NAC和囊切除术的40名日本BCa患者中,对CD34,VASH1和CA9的免疫组织化学分析.
病理完整反应 (ypT0) 和残留疾病患者之间的标记表达的比较.

主要成果:

高微血管密度,VASH1密度和CA9染色与ypT0.0相关.
VASH1密度独立预测了病理性ypT0疾病 (p=0.002).
患有高VASH1密度的患者在5年无复发生存期 (66.3%与33.3%) 中显著改善.

结论:

VASH1密度是膀癌中化疗反应的有希望的预测生物标志物.
VASH1可能有助于为BCa患者个性化新辅助化疗治疗策略.

关键词:

血管新生的产生.生物标志物生物标志物膀癌是一种癌症.化疗化疗是一种化学疗法.病理结局病理结局

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