炎症性细胞因子变异对系统性炎症概况和COVID-19严重性的影响
XueJun Deng1, Kai Tang1, Zhiqiang Wang2
1Department of Cardiology, Suining Central Hospital, Suining, 629000, Sichuan, China.
Journal of epidemiology and global health
|February 20, 2024
概括
促炎性细胞因子的遗传变异会影响COVID-19的结果. rs1800629变种与严重程度和死亡率的增加有关,而rs1800795则影响易感性.
科学领域:
- 免疫遗传学 免疫遗传学
- 传染病流行病学 传染病流行病学
- 分子生物学分子生物学
背景情况:
- 细胞因子风暴显著影响COVID-19的预后.
- 亲炎性细胞因子基因变异与细胞因子风暴有关.
- 这项研究调查了细胞因子变异是否通过细胞因子风暴调节COVID-19结果.
研究的目的:
- 为了验证这种假设,即亲炎性细胞因子变异会影响COVID-19的结果.
- 分析特定细胞因子基因变异 (rs1800795,rs1800629) 与COVID-19临床结果的关联.
- 探索这些变体与炎症标志物之间的关系.
主要方法:
- 在PubMed,Cochrane图书馆,中央,CINAHL和ClinicalTrials.gov进行了全面的文献搜索,直到2023年12月15日.
- 包括了检查rs1800795或rs1800629对COVID-19易感性,严重性,死亡率,IL-6,TNF-α或CRP水平的影响的病例控制和队列研究.
- 数据是在独立审稿人匿名审查过程后进行分析的.
主要成果:
- 分析包括47项研究,包括8305名COVID-19患者和17846名对照.
- rs1800629 A基因与较高的TNF-α和CRP水平相关,并增加了COVID-19的严重程度和死亡率.
- rs1800795 C等位基因与较高的IL-6和CRP水平有关,并增加了COVID-19的易感性.
结论:
- 亲炎性细胞因子变体rs1800629和rs1800795显著影响系统性炎症和COVID-19结果.
- rs1800629变种显示出作为严重COVID-19的遗传标记物的潜力.
- 这些发现突显了遗传因素在COVID-19病原和预后中的作用.
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