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Updated: Jul 9, 2026

A Quantitative Fitness Analysis Workflow
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用AnnealDCA推断化蛋白质健身景观的推断

Luca Sesta1, Andrea Pagnani1,2,3, Jorge Fernandez-de-Cossio-Diaz4

  • 1Department of Applied Science and Technology, Politecnico di Torino, Torino, Italy.

PLoS computational biology
|February 20, 2024
PubMed
概括

我们开发了AnnealDCA,这是一种机器学习工具,可以从测序数据中预测蛋白质功能. 这种计算方法可以识别特定任务的最佳蛋白质变体,克服实验选方法的局限性.

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...