生物修饰剂与儿科中潜伏结核病的发展之间的关系
Tugba Bedir Demirdag1, Aslinur Ozkaya Parlakay1, Fatma Aydin2
1Department of Pediatric Infectious Diseases, Ankara City Hospital, Ankara, Turkey.
Journal of infection in developing countries
|February 20, 2024
概括
生物修饰剂增加了儿童结核病的风险. 近10%的患者患有潜伏结核病,年龄较大的儿童和更长的治疗时间是危险因素.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 传染病流行病学 传染病流行病学
- 免疫调节疗法 免疫调节疗法
背景情况:
- 生物修饰剂对于治疗儿科类风湿性疾病至关重要.
- 这些疗法与mycobacterial感染的风险增加有关,包括结核病 (TB).
- 对接受这些药物的儿科患者进行结核病发展监测是必不可少的.
研究的目的:
- 为了记录使用生物修饰剂治疗的儿科患者肺结核 (TB) 发病率.
- 在这一群体中确定结核病发展的潜在风险因素.
- 分析特定生物病原体与结核病风险之间的关联.
主要方法:
- 在2010-2020年间接受生物修饰剂治疗的儿科患者的回顾性研究.
- 结核病发展的评估,包括结核素皮肤测试 (TST) 的结果.
- 对患者人口统计,治疗持续时间和使用的特定生物药物的分析.
主要成果:
- 在72名患者中,7名 (9.7%) 患有潜藏性结核病.
- 患有潜在结核病的患者年龄明显大 (p = 0.01).
- 患有潜在结核病的患者的中位治疗持续时间较长 (p = 0.04).
- 与预期相反,Canakinumab与最高的TST转化率有关.
结论:
- 在接受生物治疗的儿科患者中,约有9.7%患有潜藏性结核病.
- 高龄和更长的治疗时间是潜在结核病的重要风险因素.
- 该研究强调,需要对接受生物修饰剂的儿科患者进行警的结核病查和监测,特别注意治疗持续时间和患者年龄.
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