在治疗类风湿性关节炎的生物使用过程中,非严重感染的负担
Barbara Bergmans1,2, Naomi Jessurun3, Jette van Lint3
1Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.
PloS one
|February 20, 2024
概括
在接受生物药物治疗的类风湿性关节炎患者中,非严重的感染很常见,上呼吸道感染造成了显著的,持续的负担. 了解这些感染可以帮助降低患者和社会成本.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 药物监督 药物监督 药物监督
背景情况:
- 生物疗法对于类风湿性关节炎 (RA) 管理至关重要.
- 虽然严重的感染是公认的风险,但非严重的感染更频繁,更负担.
- 有限的文献涉及RA患者使用生物药物的非严重感染的影响.
研究的目的:
- 研究使用生物制剂治疗的RA患者中非严重感染的类型和经历的负担.
- 在现实环境中量化这些感染的频率和影响.
主要方法:
- 一项前性观察性研究 (荷兰生物监测) 涉及RA患者接受生物药物治疗.
- 每两个月一次的问卷调查收集了关于药物不良反应 (ADR) 和其影响的数据.
- 药物监测和传染病专家对副作用进行了分类.
主要成果:
- 14.5%的患者报告感染,总共有421个不良反应被归类为可能或确定的感染.
- 上呼吸道感染是最常见的,其特点是复发/持久性.
- 这些感染的中位影响得分为3.0 (IQR2.0-3.0),随着时间的推移保持稳定.
结论:
- 非严重的感染发生率要高得多 (每100个患者年为77.1),而不是严重的感染 (每100个患者年为1.3).
- 复发的上呼吸道感染对服用生物药物的RA患者来说是一个重大的,持续的负担.
- 识别和管理这些不严重的感染对于减轻个人和社会经济成本至关重要.
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