针对可逆男性避孕的核受体核心压缩剂
Suk-Hyun Hong1, Glenda Castro1, Dan Wang1
1Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
概括
研究人员开发了一种针对精子生成的新口服男性避孕药. 这种非荷尔蒙方法破坏了基因表达,可逆地阻止生育而不影响性欲,提供了一个新的计划生育选择.
科学领域:
- 生殖生物学 生殖生物学
- 分子内分泌学分子内分泌学
- 药理学 药理学是指药理学的学科.
背景情况:
- 只有有限的男性避孕方法可供选择,避孕套是不可靠的,精管切除术是侵入性的,难以逆转.
- 几乎一半的怀孕是意想不到的,这强调了需要有效的男性计划生育方法.
研究的目的:
- 开发一种新的非荷尔蒙口服男性避孕药.
- 调查视网体和甲状腺激素受体 (SMRT) 综合体沉默媒介在精子生成中的作用.
- 为了验证男性避孕的SMRT抑制器综合体的药理学向.
主要方法:
- 用小鼠的基因工程 (SMRTmRID) 来破坏SMRT-RAR结合并研究精子生成.
- 在小鼠中,口服用一个组素脱乙酶抑制剂来阻断SMRT复合物的作用.
- 评估对精子生成,生育能力和性欲的影响.
主要成果:
- 在SMRTmRID小鼠中,SMRT-RAR结合的破坏导致了对精子生成至关重要的基因表达模式的破坏.
- 慢性,低剂量口服的基因素脱乙酶抑制剂可逆地阻断了小鼠的精子生成和生育能力.
- 在不影响性欲的情况下实现了避孕效果.
结论:
- RAR和SMRT之间的相互作用对男性生育能力至关重要.
- 对SMRT抑制剂复合物的药理向是开发非荷尔蒙男性避孕药的可行策略.
- 这种方法提供了一个潜在的可逆和有效的男性计划生育方法.
相关概念视频
Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K
Birth Control Methods
251
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
251
Methods of Nuclear Reprogramming
1.8K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K
Co-activators and Co-repressors
7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K
Experimental RNAi
6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
Eukaryotic Transcription Inhibitors
9.8K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
9.8K


