基于金属有机框架的纳米材料用于调节骨质性微环境
Wenzhuo Zheng1, Zihan Meng1, Zhou Zhu1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
Small (Weinheim an der Bergstrasse, Germany)
|February 20, 2024
概括
金属有机框架 (MOFs) 提供了先进的纳米医学解决方案,用于调节骨质生微环境 (OME). 本综述探讨了MOF复合材料,通过解决感染,炎症和氧化应激来治疗骨疾病.
科学领域:
- 生物材料科学 生物材料科学
- 纳米医学是一种纳米医学.
- 再生医学是一种再生医学.
背景情况:
- 人口老龄化面临着骨疾病患病率的增加.
- 骨质平衡因感染,炎症和氧化应激而受到破坏.
- 外源性策略对于调节骨质性微环境 (OME) 是至关重要的.
研究的目的:
- 审查金属有机框架 (MOFs) 在监管OME中的作用.
- 探索基于MOF的纳米材料用于骨疾病管理.
- 引导开发用于治疗应用的先进纳米材料.
主要方法:
- 在OME法规中对MOF应用的综合文献综述.
- 分析MOFs作为金属离子捐赠者,药物载体,纳米酶和光敏剂.
- 讨论各种功能MOF复合材料及其机制.
主要成果:
- 在纳米医学中,MOFs在治疗骨疾病方面显示出显著的潜力.
- 可以设计MOF来诱导,调制,保护和支持OME.
- 不同的MOF复合物在骨再生和疾病管理中表现出多方面的作用.
结论:
- 基于MOF的纳米材料对外源性OME调节有希望.
- 针对性设计的MOF复合材料可以增强骨疾病管理策略.
- 本综述为未来骨疗法中复杂纳米材料的发展提供了洞察力.
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