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自动化胰岛素输送系统使用现实世界的证据

Elizabeth G Considine¹, Jennifer L Sherr¹

¹Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.

Diabetes technology & therapeutics

|February 20, 2024

概括

自动化胰岛素输送 (AID) 系统显著改善了1型糖尿病 (T1D) 的血糖控制在现实世界中使用,证实了关键试验的好处. 这些先进的技术正在成为标准护理,为T1D患者提供更好的葡萄糖管理.

科学领域:

内分泌学和代谢性疾病.
医疗技术和设备医疗技术和设备
糖尿病研究研究糖尿病研究

背景情况:

关键试验表明,自动化胰岛素输送系统 (AID) 改善了1型糖尿病 (T1D) 的血糖控制.
在现实世界中,AID系统的有效性需要超越受控试验设置进行评估.

研究的目的:

评估AID系统的关键试验结果如何转化为现实世界的商业用途.
系统地审查对AID在1型糖尿病 (T1D) 的回顾性研究.

主要方法:

对2018年以后发表的研究进行PubMed和EMBASE的系统审查.
包括5名T1D非怀孕个体的研究,重点关注血糖结果和自动化时间.
对20项符合条件的研究进行重复查和数据提取,代表了171,209名个人.

主要成果:

大多数研究 (71%) 显示AID的目标范围 (70-180 mg/dL) 的时间改善>10%.
观察到HbA1c (0.1%-0.9%) 和葡萄糖管理指标 (GMI) (0.1%-0.4%) 的显著降低.
大多数研究报告了在范围以下的时间稳定或减少 (<70 mg/dL),自动化时间>90%.

结论:

现实世界的数据证实了关键试验发现,证明了AID在多种T1D种群中的持续的血糖益处.
艾滋病辅助系统正在成为T1D管理的标准护理.
了解患者的获取,覆盖和支持对于将AID纳入日常生活至关重要.

关键词:

自动提供胰岛素的自动化输送.一个闭环的闭环循环.现实世界的真实世界.追溯性是可以追溯的.时间范围内的时间范围.

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