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在Medtronic的自动化胰岛素输送系统中减轻糖尿病负担
Gregory P Forlenza1, Zheng Dai2, Fang Niu2
1Barbara Davis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Diabetes technology & therapeutics
|February 20, 2024
概括
与MiniMedTM 670G相比,MiniMedTM 780G系统显著降低了糖尿病管理负担,并改善了血糖控制. 这种先进的混合闭环系统为用户提供了更少的日常交互和更好的射程时间.
科学领域:
- 糖尿病 技术 技术
- 内分泌学 在内分泌学.
- 医疗器械 医疗器械
背景情况:
- MiniMedTM 780G (MM780G) 先进的混合闭环系统基于之前的代,提供增强的基底自动化和低葡萄糖保护.
- 虽然先前的研究集中在血糖控制上,但MM780G对减轻糖尿病管理的日常负担的影响需要进一步描述.
研究的目的:
- 为了比较MM780G系统与GuardianTM 4传感器 (G4S) 与MiniMedTM 670G系统与GuardianTM传感器3 (GS3) 的糖尿病管理负担和血糖结果.
- 分析用户向MM780G+G4S系统转换的真实世界数据 (RWD).
主要方法:
- 对使用MM670G+GS3和MM780G+G4S系统的成人和儿童的关键试验数据进行比较分析.
- 对美国用户从MM770G+GS3切换到MM780G+G4S的RWD进行分析.
- 利用新的五角形复合度量来评估糖尿病管理负担,以及传统的血糖结果度量和系统负担指标 (例如,闭环出口,指针).
主要成果:
- 与MM670G相比,MM780G系统显示,糖尿病管理负担在成年人中显著降低了-22.8%,在儿童中降低了-28.5%.
- 观察到血糖控制的改善,包括范围内的时间增加 (+3.1%的成年人, +6.4%的儿童) 和范围以下时间减少 (-1.8%的成年人, -0.7%的儿童).
- 闭环使用显著增加,而闭环退出和每日指针测试在成人和儿科队列中大幅减少,与RWD发现一致.
结论:
- MiniMedTM 780G系统,特别是GuardianTM 4传感器,在减少糖尿病管理的日常负担方面提供了显著的优势.
- 该系统提供了增强的血糖控制,其特点是改善时间范围和降低低血糖.
- 与MiniMedTM 670G系统相比,更少的系统交互,如闭环出口和指针测试,有助于用户对糖尿病管理的体验更轻松.
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