联合运动训练对老年癌症患者的炎症概况的影响,这些患者接受了全身疗法治疗
Hugo Parent-Roberge1,2, Adeline Fontvieille1,2, René Maréchal1,2
1University of Sherbrooke, Faculty of Physical Activity Sciences, 2500, boul. de l'Université, Sherbrooke, QC, J1K 2R1, Canada.
Brain, behavior, & immunity - health
|February 20, 2024
概括
在老年癌症患者中,联合炼训练并没有显著改变炎症概况或与癌症相关的疲劳 (CRF). 然而,减少CRF的趋势表明潜在的好处,可能与炼有关.
科学领域:
- 老年病学和瘤学
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
背景情况:
- 与癌症相关的疲劳 (CRF) 显著影响老年癌症患者的生活质量和功能状态.
- 癌症治疗期间炎症活动的增加被怀疑是CRF发展的关键因素.
- 已知联合有氧和阻力运动可以减轻CRF,可能是通过抗炎机制.
研究的目的:
- 评估12周联合运动训练对接受全身治疗的老年癌症患者的炎症概况的影响.
- 调查炎症概况变化与CRF之间的关联.
- 在这个人群中探索运动的潜在抗炎作用.
主要方法:
- 开始化疗/激素治疗的20名老年非转移性癌症患者被随机分配到12周的运动或控制 (伸展) 组.
- 主要结局包括炎症标志物 (KYN/TRP比) 和CRF (FACIT-F).
- 二次结果评估了营养,荷尔蒙,身体组成,体力活动和治疗变量.
主要成果:
- 在干预后的任何一组中都没有观察到炎症概况的显著恶化.
- 与癌症相关的疲劳 (CRF) 没有显著变化,尽管在运动组 (p=0.10) 发现了减轻疲劳的趋势.
- 在KYN/TRP比率和先前治疗延迟之间发现了显著的相关性.
结论:
- 运动可能会对CRF产生积极影响,但这种效果并没有通过显著调节促炎性细胞因子配置来调节.
- 运动组IL-6/IL-10比率的下降表明了潜在的抗炎作用.
- 化疗治疗的急性影响可能影响了炎症测量,可能掩盖了运动引起的变化.
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