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高剂量口服的耐受性-THC:对人类实验室研究设计的影响

Jan Rozanc^1,2, Linda E Klumpers^1,3, Marilyn A Huestis⁴

¹Verdient Science LLC, Denver, Colorado, USA.

Cannabis and cannabinoid research

|February 20, 2024

概括

在受控研究中,高剂量口服的delta-9-tetrahydrocannabinol (THC) 一般耐受良好. 之前有大麻经验的参与者最能容忍更高的THC剂量,报告了轻微的不良事件.

科学领域:

药理学药理学是指药理学的学科.
大麻素研究研究大麻素研究
人类临床研究人类临床研究

背景情况:

大麻中主要的精神活性化合物delta-9-tetrahydrocannabinol (THC) 经常在人类身上进行研究.
高剂量的THC有时对于研究是必要的,比如测试大麻素过量治疗方法,这引发了安全问题.
缺乏对高剂量THC研究的系统分析.

研究的目的:

审查使用高口服剂量THC (≥30毫克) 的研究.
分析高剂量THC的耐受性,主观影响和药理动力学 (PK).
为未来THC研究研究的设计提供信息.

主要方法:

一个全面的PubMed搜索确定了相关的实验室研究.
包括的研究涉及高剂量THC (≥30毫克) 的口服.
提取和分析了有关不良事件,主观影响和PK的数据.

主要成果:

涉及27个出版物的17项研究使用了高达90毫克的单剂量和高达210毫克/天的多剂量.
血THC度 (Cmax) 显示剂量成比例增加.
高剂量的THC通常耐受良好,并有轻度至中度的短暂不良事件;经常使用大麻的人最能耐受.

结论:

高口服THC剂量 (≥50毫克) 似乎在健康的成年人中得到了充分的耐受,在受控环境中有过大麻的经验.
副作用通常是轻微和短暂的,没有报告严重事件.
需要进一步的研究,但研究结果表明,在特定的研究设计中使用更高的THC剂量是可行的.

关键词:

不良事件不良事件不良事件药物动力学药物动力学可以容忍的耐受性.Δ9 - 四基可纳比诺尔

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