暴露和肺功能下降:TRAIL在慢性阻塞性肺病患者的潜在调解作用
Ying Liu1, Feng-Min Zhu2, Juan Xu2
1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China; Institute of Respiratory Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China; Center for Big Data and Population Health of IHM, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
环境暴露会使COPD患者的肺功能恶化. 与瘤亡因子相关的亡诱导质 (TRAIL) 的升高调解了这种下降,这表明它是诱导肺损伤的关键因素.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 环境 (As) 暴露与慢性阻塞性肺病 (COPD) 的进展有关.
- 肺上皮细胞亡是COPD病理生理学的已知因素.
- 与瘤亡因子相关的诱导亡联体 (TRAIL) 在As介导的COPD肺功能变化中的特定作用尚不清楚.
研究的目的:
- 为了研究血水平,血清 TRAIL 和COPD患者的肺功能之间的关系.
- 为了确定 TRAIL 是否介导对肺功能下降COPD的影响.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量239名COPD患者的血清TRAIL水平.
- 感应合血质谱法 (ICP-MS) 确定了血液中的 (As) 水平.
- 分析了As,Trail和肺功能参数 (FEV1,FVC,FEV1/FVC%,FEV1%) 之间的相关性.
主要成果:
- 血中As水平显示出与肺功能具有负面的,剂量依赖的相关性,As的增加与FEV1,FVC和FEV1%的降低有关.
- 在血液A和血清TRAIL水平之间观察到积极的剂量反应相关性.
- 血清TRAIL水平升高与肺功能有负面关联,并显著介导FVC,FEV1和FEV1%的As诱导下降.
结论:
- 在COPD患者中,血水平与肺功能下降和血清 TRAIL 增加正相关.
- 较高的TRAIL水平似乎是COPD中引起的肺功能障碍的重要调解机制.
- 这些发现凸显了TRAIL作为相关的COPD的潜在生物标志物和治疗目标.
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