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通过基于多式神经成像数据的多类分类模型区分精神分裂症和双相情感障碍

Ming Chen¹, Xiaowei Xia², Zhuang Kang³

¹Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Mental Health Institute, Guangdong ProvincialPeople's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Journal of psychiatric research

|February 20, 2024

概括

多模式神经成像确定了精神分裂症 (SZ) 和双相情感障碍 (BP) 的共享和独特的神经生物标志物. 关键发现包括改变的大脑结构和连接性,有助于差异诊断.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

精神分裂症 (SZ) 和双相情感障碍 (BP) 是不同的精神疾病,症状重叠.
准确的差异诊断对于有效的治疗至关重要,但可能具有挑战性.
识别客观的神经生物标志物可以提高诊断准确性.

研究的目的:

使用多式神经影像识别神经生物标志物来区分精神分裂症 (SZ),双相情感障碍 (BP) 和健康对照 (HC).
探索SZ和BP的共享和特定的神经成像签名.

主要方法:

使用结构性MRI (sMRI),扩散张力成像 (DTI) 和休息状态fMRI (rs-fMRI) 数据,从113名参与者中构建了多类分类模型.
采用了具有递归特征消除 (RFE) 和留出一次的交叉验证的支持矢量机器 (SVM).
特征提取产生了272个 (sMRI),200个 (DTI) 和1875个 (rs-fMRI) 的特征.

主要成果:

该分类模型的整体准确率为70.8%.
对SZ和BP的共享生物标志物包括左皮层厚度增加和左上边缘回形中区域功能连接强度 (rFCS) 降低.
特定的生物标志物被确定为BP的左上额头尾囊中小分离异性变异的降低,SZ的左下头顶区域的rFCS的降低.

结论:

多模式神经成像有效地区分SZ,BP和HC.
已确定的神经生物标志物,特别是来自rs-fMRI,sMRI和DTI,为差异诊断提供了潜力.
这些发现提高了对精神分裂症和双相情感障碍独特和重叠的神经支的理解.

关键词:

双极性障碍是一种双极性障碍.多类支向量机器多类支向量机器多模式核磁共振 (MRI) 是一种多模式核磁共振.精神分裂症是一种精神分裂症.

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