相关实验视频

Updated: May 5, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

可注射的病理微环境响应性抗炎水凝,用于改善椎间盘退化

Lei Liu¹, Wantao Wang², Lin Huang¹

¹Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

|February 20, 2024

概括

这项研究引入了一种可注射的水凝,该水凝释放抗炎药物,以应对椎间盘退化 (IDD) 微环境. 这种方法促进核脉 (NP) 细胞修复,并保留IDD模型中的磁盘结构.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
药物输送系统药物输送系统

背景情况:

慢性炎症和核脉 (NP) 细胞功能障碍导致椎间盘退化 (IDD).
可注射,微环境响应的水凝通过适应动态的病理环境,为IDD治疗提供了潜在的潜力.

研究的目的:

开发一种可注射,病理微环境响应的水凝,用于控制释放抗炎药物治疗IDD.
促进退行性NP细胞的修复和保持磁盘的完整性.

主要方法:

通过通过动态乙烯 Ester 合成一种基于凝的水凝,这种水凝是用乙烯酸修饰的凝甲基烯 (GP) 与表甲基-3-酸盐 (EGCG) 结合的.
评估了水凝的特性,包括可降解性,可注射性,抗氧化和抗炎作用,以及生物相容性.
在高活性氧物种 (ROS) 和酸性条件下评估EGCG释放,并在试验室中评估NP细胞的细胞保护作用. 使用大鼠IDD模型进行的体内研究.

主要成果:

水凝显示出出色的可降解性,可注射性,抗氧化,抗炎和生物相容性.
EGCG释放对高ROS水平和酸性条件有反应,这是IDD病理微环境的特征.
在体外,水凝保护了NP细胞免受氧化应激和炎症性细胞因子的影响. 在体内,它改善了IDD,保持了圆盘高度和NP组织结构.

结论:

开发的水凝系统在病态微环境中表现出生物相容性和响应性药物释放.
这种水凝平台通过有效地提供抗炎药物,显示出治疗椎间盘退化的巨大潜力.
该系统能够适应IDD微环境并促进NP修复的能力突显了其作为先进药物输送平台的承诺.

关键词:

凝水凝是一种凝.炎症调节剂炎症调节剂炎症调节剂椎间盘变性修复椎间盘变性修复最少侵入性的注射方式.响应式释放的释放方式

更多相关视频

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

相关概念视频

Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...