体重指数和乳腺癌风险在更年期的年龄左右
Ann Von Holle1, Hans-Olov Adami2, Laura Baglietto3
1Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Cancer epidemiology
|February 20, 2024
概括
高体重指数 (BMI) 与更年期前乳腺癌风险降低有关,但更年期后风险更高. 这项研究发现,风险增加的转变发生在55岁之后,而不是之前.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 内分泌学 在内分泌学.
背景情况:
- 高体重指数 (BMI) 与更年期前乳腺癌风险降低有关,但更年期后风险增加.
- 这种BMI-乳腺癌风险逆转的确切更年期过渡点尚不清楚.
- 了解这种转变对于阐明脂肪在乳腺癌病因学中的作用至关重要.
研究的目的:
- 确定BMI与45-55岁女性乳腺癌风险之间的特定年龄关联.
- 确定更年期状态过渡点,即BMI对乳腺癌风险的影响从保护性转变为有害性.
主要方法:
- 分析了16项前性研究中的609,880名女性,重点关注45-55岁的女性.
- 利用分片指数增剂混合模型来评估BMI对不同绝经状态 (绝经前期,自然绝经后期,干预诱导的绝经后期,子宫切除术后期) 乳腺癌的危险比 (HR).
- 采用恒定的BMI HR模型,证明最适合数据.
主要成果:
- 五个单位的BMI增加和乳腺癌风险之间的关联是HR=0.87 (绝经前) 和HR=0.88 (没有卵巢切除术的子宫切除术后).
- 在自然更年期 (HR=1.00) 和干预诱导的卵巢功能丧失 (HR=0.99) 后,这种关联几乎是中性的.
- 这些发现表明,在整个45-55岁年龄范围内存在保护性或中性关联.
结论:
- 体重指数和乳腺癌之间的风险关联在45-55岁期间仍然低于或接近1岁.
- 转变为BMI与乳腺癌风险之间的积极关联发生在55岁以后.
- 这表明脂肪在乳腺癌风险中的作用可能在更晚的绝经后几年发生显著变化.
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