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Updated: Jul 2, 2025

A Nonsequencing Approach for the Rapid Detection of RNA Editing
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A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

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一个 uracil-N-glycosylase 变体的蛋白质语言模型辅助优化使可编程 T-to-G 和 T-to-C 基编辑成为可能

Yan He1, Xibin Zhou2, Chong Chang3

  • 1Fudan University, 220 Handan Road, Shanghai 200433, China; School of Medicine, Westlake University, Hangzhou, Zhejiang 310014, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310014, China; Research Center for Industries of the Future (RCIF), Westlake University, Hangzhou, Zhejiang 310014, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310014, China; Westlake Center for Genome Editing, Westlake Laboratory of Life Sciences and Biomedicine, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang 310024, China.

Molecular cell
|February 20, 2024
PubMed
概括

研究人员使用蛋白质语言模型开发了一种新的基编辑器 (BE),以创建一种能纠正特定DNA突变的酶变体 (eTDG). 这一进步使新的基因编辑策略成为可能,并纠正了小鼠糖尿病突变.

关键词:
C>G 基础编辑克里斯普尔是什么意思?克里斯普尔是什么意思?从T到C的基础编辑.从T到G的基础编辑.基础切除修复的基础切除修复葡萄糖酶衍生基基编辑器蛋白质语言模型的模型

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