多巴胺神经元活动编码即将到来的逆侧运动序列的长度
Marcelo D Mendonça1, Joaquim Alves da Silva2, Ledia F Hernandez3
1Champalimaud Research, Champalimaud Foundation, 1400 038 Lisbon, Portugal; Champalimaud Clinical Centre, Champalimaud Foundation, 1400 038 Lisbon, Portugal; NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon 1169 056, Portugal.
Current biology : CB
|February 20, 2024
概括
黑色物质紧体 (SNc) 中的多巴氨基神经元激发相反的运动,影响序列的长度. 这一发现为运动控制和帕金森病 (PD) 提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 帕金森病研究 帕金森病研究
背景情况:
- 黑色物质紧体 (SNc) 中的多巴氨基神经元 (DAN) 对于运动速度至关重要,它们的损失导致帕金森病 (PD) 中的布拉迪基尼西亚.
- PD也会影响运动活力,导致较短的运动序列,但SNc DANs在这方面的作用尚不清楚.
研究的目的:
- 调查SNc DAN活动与运动序列的长度之间的关系.
- 为了确定SNc DAN是否对ipsilateral和contralateral运动进行差异调节.
主要方法:
- 在小鼠中SNc DAN活动的成像,小鼠执行自由移动的操作任务,涉及前肢序列.
- 分析与ipsilateral和contralateral运动启动和序列长度相关的DAN活动.
- 评估单边多巴胺耗尽后的运动序列长度.
主要成果:
- 在ipsilateral和contralateral序列之前,SNc DANs的相似比例增加了活动.
- 对于反侧行动来说,SNc DAN活动增加的幅度更大,并且与反侧序列长度相关.
- 奖励调节的DANs没有表现出横向活动,单边多巴胺耗尽损害了逆侧序列长度,但不是双侧.
结论:
- 参与运动启动的SNc DANs提供了一个特定的信号,激发相反的运动,影响序列长度.
- 这些发现表明,SNc DANs编码的不仅仅是一个一般的动机信号,在PD相关的运动控制中发挥特定的作用.
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