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在扩散型大B细胞淋巴瘤中检测初始骨髓参与的检测性能和预后价值:单一中心18F-FDG PET/CT和骨髓活检评估研究研究

Andrej Doma^1,2, Katarina Zevnik^1,2, Andrej Studen^3,4

¹Department of Nuclear Medicine, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Radiology and oncology

|February 20, 2024

概括

¹⁸F-FDG PET/CT是一种高度准确的,非侵入性的工具,用于检测扩散性大B细胞淋巴瘤 (DLBCL) 中的骨髓参与 (BMI),其表现优于传统的骨髓活检 (BMB),并显示出有利的生存结果.

科学领域:

在瘤学瘤学.
核医学就是核医学.
诊断成像诊断成像诊断成像

背景情况:

在扩散性大B细胞淋巴瘤 (DLBCL) 中检测骨髓参与 (BMI) 传统上使用侵入性骨髓活检 (BMB).
F-FDG PET/CT为BMI评估提供了一个非侵入性成像替代方案.
BMB 的局限性需要对先进的成像技术进行评估.

研究的目的:

评估F-FDG PET/CT在检测DLBCL骨髓参与方面的诊断性能.
评估F-FDG PET/CT和BMB发现之间的一致性.
确定BMI对DLBCL患者生存结果的影响.

主要方法:

对145名II-IV期DLBCL患者的回顾性分析.
基线F-FDG PET/CT和BMB结果的比较.
评估诊断准确度指标 (灵敏度,特异性,PPV,NPV,准确度) 和生存分析.

主要成果:

在26.2%的患者中,F-FDG PET/CT检测到BMI,而在BMB患者中,这一比例为12.4%.
对于BMI检测,PET/CT显示出高灵敏度 (88.4%),特异性 (100%) 和准确性 (96.5%).
在79.3%的患者中观察到一致的结果;BMI没有显著影响整体存活率 (OS).

结论:

在DLBCLBMI检测方面,F-FDG PET/CT表现出比BMB更高的诊断准确度和性能.
这项研究强调了DLBCL患者的有利的5年OS率,与之前的一些报告形成鲜明对比.
非侵入性F-FDG PET/CT是DLBCL阶段和预后的一个有价值的工具.

关键词:

18F-FDG 关于PET/CT 的研究扩散大的B细胞淋巴瘤.活组织活检骨髓骨髓骨髓骨髓骨髓总体存活率总体存活率

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