在癌症中的sarcopenic肥胖症
Mihaela Jurdana1, Maja Cemazar1,2
1Faculty of Health Sciences, University of Primorska, Izola, Slovenia.
Radiology and oncology
|February 20, 2024
概括
肥胖症,一种肌肉损失和多余脂肪的情况,越来越多地影响癌症患者,恶化结果. 本综述澄清了癌症的定义,流行率和癌症的共享机制.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 代谢医学是一种代谢医学.
背景情况:
- 肥胖症 (sarcopenic obesity) 是一种临床疾病,结合了肥胖症 (肌肉质量和功能损失) 和肥胖症 (多余的脂肪质量).
- 它主要影响老年人,但在癌症患者中越来越多地被发现.
- 这种情况与癌症的不良结果有关,包括治疗反应较差,长时间住院治疗,残疾和生存率降低.
研究的目的:
- 审查癌症患者的sarcopenic肥胖的定义和诊断标准.
- 描述不同癌症类型中形肥胖的流行情况.
- 阐明了sarcopenic肥胖和致癌之间共同的潜在机制.
主要方法:
- 关于肉骨肥胖和癌症研究的文献综述.
- 对定义,诊断标准和流行数据的分析.
- 探索生物机制,包括氧化应激,炎症和肌肉蛋白表达.
主要成果:
- 由于定义和诊断方法的差异,癌症患者的sarcopenic肥胖症的患病率估计有很大差异.
- 分享的机制,如氧化应激,脂毒性,全身炎症和改变的肌蛋白信号,都与sarcopenic肥胖症和癌症发展/进展有关.
- 肥胖症与癌症患者的负面临床结果有关.
结论:
- 需要标准化定义和诊断标准,以准确评估癌症中sarcopenic肥胖的流行率.
- 了解共享的病理生理路径对于开发有针对性的干预措施至关重要.
- 巨型肥胖症在癌症治疗中构成了重大挑战,影响了预后和治疗疗效.
相关概念视频
01:24Obesity
501
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
501
01:21Cancer Survival Analysis
346
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
346
01:03Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
02:12What is Cancer?
10.7K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.7K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K