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阿沃松对猪精子功能的不良影响:破坏蛋白激酶A活动和氨酸酸化
Woo-Jin Lee1, Ju-Mi Hwang1, Jae-Hwan Jo2
1Department of Animal Science and Biotechnology, Kyungpook National University, Sangju, Gyeongsangbuk-do 37224, Republic of Korea.
Reproductive toxicology (Elmsford, N.Y.)
|February 20, 2024
概括
化品中常见的紫外线过器阿沃 (AVO) 通过破坏关键细胞过程,对精子功能和男性生育能力产生负面影响. 需要进一步的研究来了解它对生殖健康的全部影响.
科学领域:
- 生殖毒理学 生殖毒理学
- 环境健康 环境健康
- 生物化学 生物化学
背景情况:
- 青 (AVO) 是个人化品中广泛使用的紫外线过器.
- 在水生环境和人类生物样本中记录了AVO暴露.
- 新出现的证据表明,AVO具有内分泌干扰特性,引发了对其对男性生殖健康的影响的担忧.
研究的目的:
- 为了研究阿沃 (AVO) 在容量化过程中对精子关键功能的影响.
- 评估AVO对精子运动,电容状态,ATP水平,活力和关键信号通路的影响.
主要方法:
- 野猪精子暴露于不同度的AVO.
- 评估了精子的运动性,动力学,电容性,细胞内ATP和活力.
- 西部斑点分析用于评估蛋白激酶A (PKA) 活性和氨酸酸化.
主要成果:
- 高AVO度 (50和100μM) 显著降低了精子运动性和运动参数.
- 暴露于AVO导致精子容量的剂量依赖性下降.
- 对PKA活性和氨酸酸化的异常变化观察到以剂量依赖的方式,而不会对体反应或细胞活力产生显著影响.
结论:
- 青 (AVO) 通过涉及PKA和氨酸酸化的机制损害精子功能,特别是运动性和电容性.
- 虽然没有直接的细胞毒性,但AVO对精子功能的影响引起了男性生育能力的担忧.
- 在消费品中安全使用AVO需要仔细考虑,因为它可能对男性生殖健康产生不利影响.
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