来自Rosmarinus officinalis的具有抗神经炎症活性的阿比坦二甲
Tang Zhou1, Ji Wang1, Zhiqi Lin1
1School of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, PR China.
Fitoterapia
|February 20, 2024
概括
来自迷香 (Rosmarinus officinalis) 的六种新型阿比二甲类药物显示出显著的抗神经炎症作用. 这些化合物显示出开发神经保护剂的潜力,以防止炎症诱导的神经损伤.
科学领域:
- 自然产品化学 自然产品化学
- 神经药理学神经药理学
- 药用化学 医学化学
背景情况:
- 迷花 (Rosmarinus officinalis) 是一个丰富的生物活性化合物的来源.
- 阿比坦二烯酸是一种具有多种生物活性的自然产品.
- 神经炎症在各种神经疾病中起着至关重要的作用.
研究的目的:
- 从Rosmarinus officinalis中分离和描述新型的阿比坦二特类物种.
- 评估这些孤立化合物的抗神经炎症潜力.
- 为了探索作为神经保护剂的Rosmarinus officinalis衍生型二甲的治疗价值.
主要方法:
- 使用HRESIMS,NMR和ECD,对12种阿比二甲的隔离和结构阐明.
- 化学命名法分配给新型化合物作为罗斯马林素Q-V (1-6).
- 使用脂聚糖 (LPS) 诱导的BV2细胞模型对抗神经炎症活性进行体外评估.
主要成果:
- 确定了6种新的阿比二类物质,包括具有独特6/6/5骨架的罗斯马里努辛Q和α,β不和的五元素.
- 化合物5,8,9,11和15在测试度 (10,20,40μM) 中表现出显著的抗神经炎症活性.
- 之前的化合物 (13-16) 也对观察到的生物活性作出了贡献.
结论:
- 罗斯马林斯官员园 (Rosmarinus officinalis) 含有各种各样的阿比二甲类植物,具有显著的抗神经炎症特性.
- 已识别的化合物,特别是罗斯马林素Q,作为神经保护药物开发的化合物具有前景.
- 这些发现支持迷香的民族植物学用途,并突出了它在治疗神经炎症相关疾病方面的潜力.
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