息性放射治疗:生存预后因素 - 单中心回顾性队列研究
Sian Cooper1, Mary Denholm2,3, Abdul Shawal Malek4
1Southend University Hospital, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK siancooper1@nhs.net.
BMJ supportive & palliative care
|February 20, 2024
概括
确定息性放射治疗 (PR) 的预后因素至关重要. 低绩效状态 (PS) 和进展性疾病 (PD) 在接受PR的患者中显著影响整体生存率和30天死亡率.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 抚慰性护理是一种缓解性护理.
背景情况:
- 息性放射治疗 (PR) 旨在缓解非治愈性恶性瘤患者的症状.
- 选择合适的候选人PR是具有挑战性的,因为可变的生存率.
- 识别预后因素可以优化PR患者的选择和结果.
研究的目的:
- 在PR后确定总生存期 (OS) 和30天死亡率 (30DM) 的预后因素.
- 在现实世界患者队列中评估这些预后因素.
主要方法:
- 对214名成年患者的回顾性分析,在英国的一个中心接受PR.
- 收集的数据包括人口统计,瘤特征,治疗细节,表现状况 (PS),进展性疾病 (PD),阿片类药物/类固醇使用以及血红蛋白水平.
- 考克斯和后勤回归模型被用来评估生存预测因素和30DM风险因素.
主要成果:
- 30天死亡率 (30DM) 是14%.
- 糟糕的绩效状态 (PS) 与更糟糕的OS (p=0.01) 有显著的关联.
- 患有PS3的患者的中位数生存期为75天,并增加了30DM风险 (OR6.2,p=0.03).
- 在辐射场外的渐进性疾病 (PD) 预测了明显更糟糕的生存状况 (HR 5.24,p<0.001).
结论:
- 低绩效状态 (PS) 和进展性疾病 (PD) 是接受息性放射治疗的患者整体存活率和30天死亡率的显著预后指标.
- 建议在潜在的队列中进一步验证.
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