产前甲酸盐暴露和2岁双胞胎的神经发育差异
Han Xiao1, Liqin Hu1, Tingting Tang2
1Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
BMC public health
|February 20, 2024
概括
产前甲酸盐暴露,特别是DEHP代谢物,与双胞胎的神经发育差异有关. 这些关联在单双双胞胎中更为强烈,这表明怀孕早期的临界暴露窗口.
科学领域:
- 环境健康 环境健康
- 发展心理学 发展心理学
- 毒理学 毒理学 毒理学
背景情况:
- 关于产前甲酸盐暴露和单体神经发育的先前研究产生了不一致的结果.
- 父母,产科和遗传因素可能会混单项研究的结果.
- 一个共同的双胞胎控制设计将遗传和共享的环境影响最小化.
研究的目的:
- 研究产前甲酸盐暴露与双胞胎神经认知发育之间的关联.
- 为了确定特定的甲酸盐代谢物和影响神经发育的临界暴露窗口.
- 为了利用一个共同的双胞胎控制设计来减少混因素.
主要方法:
- 使用了97对来自武汉双胞胎出生队伍的双胞胎母亲的共同双胞胎控制设计.
- 在母亲的尿液中测量了14种甲酸盐代谢物,跨越了三个季度.
- 在2岁时使用贝利婴儿发育尺度 (第二版) 和多信息者模型评估神经发育差异.
主要成果:
- 在第一季度暴露于MEOHP,MEHHP和DEHP时,与双胞胎内精神发育指数 (MDI) 的差异有显著的积极关联.
- 几个甲酸盐代谢物 (MEP,MiBP,MBP,MBzP,DEHP代谢物) 与神经发育差异之间的关联在单胆双子 (MCDA) 双胞胎与二胆双子 (DCDA) 双胞胎相比更强.
结论:
- 产前甲酸盐暴露与MCDA双胞胎的神经发育差异显著相关.
- 这些发现凸显了MCDA双胞胎在妊娠期间对环境暴露的敏感性.
- 建议在更大的纵向研究中进一步验证.
相关概念视频
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Behavioral Genetics and Its Designs
366
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
366


