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对AOPP,IL-6和GDF15的增量值用于识别阻塞性睡眠呼吸暂停患者的动脉硬化

Xinxin Li^1,2,3, Wen Liu^1,2,3, Yonghuai Wang^1,2,3

¹Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Shenyang, 110001, Liaoning, China.

European journal of medical research

|February 20, 2024

概括

增长差异化因子15 (GDF15) 在阻塞性睡眠呼吸暂停 (OSA) 患者的动脉硬化鉴定中具有独立价值. GDF15超越了传统的风险因素和生物标志物,如AOPP和IL-6,提高了诊断准确度.

科学领域:

心血管医学心血管医学
睡眠医学睡眠医学
生物标志物研究生物标志物研究

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与心血管风险增加有关.
动脉样硬化是OSA患者的一个关键并发症.
在OSA中确定可靠的动脉样硬化生物标志物至关重要.

研究的目的:

评估先进氧化蛋白产物 (AOPP),介质蛋白6 (IL-6) 和生长分化因子15 (GDF15) 在鉴定动脉样硬化时的独立和增量价值.
将这些生物标志物的诊断性能与OSA患者的临床风险因素和呼吸暂停-缺氧指数 (AHI) 进行比较.

主要方法:

104名被诊断为OSA的患者接受了多睡眠学.
动脉样硬化被评估使用动脉超快脉冲波速度.
使用ELISA测量了AOPP,IL-6和GDF15的血清水平.

主要成果:

动脉硬化患者的AOPP,IL-6和GDF15水平明显较高.
GDF15与动脉样硬化有着强烈的独立关联,其表现优于AOPP和IL-6.
GDF15显示了动脉样硬化检测曲线下的最高面积 (0.85),并显著改善了后勤回归模型.

结论:

GDF15是一种有价值的独立生物标志物,用于识别OSA患者的动脉样硬化.
GDF15提供了超越临床因素和其他生物标志物的增量诊断价值.
GDF15有可能成为管理OSA相关心血管并发症的关键诊断工具.

关键词:

动脉硬化是动脉硬化的一种疾病.增长差异化因子 15 15 炎症炎症是一种炎症.阻塞性睡眠呼吸暂停症是什么氧化应激是一种氧化应激.

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