生物模拟计算机与大脑的通信,通过外围神经刺激增强自然的触摸感觉
Giacomo Valle1, Natalija Katic Secerovic1,2,3, Dominic Eggemann1
1Laboratory for Neuroengineering, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, Zürich, Switzerland.
Nature communications
|February 20, 2024
概括
这项研究介绍了一种仿生神经刺激框架,模仿自然的感官输入,改善移动性并减少感官运动缺陷的个体的精神努力.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 辅助技术 辅助技术 辅助技术
背景情况:
- 周围神经刺激对感官运动缺陷有希望,但缺乏自然的感官反.
- 当前的神经刺激方法往往无法提供直观和生理上可信的感官体验.
研究的目的:
- 设计和测试一种生物模拟神经刺激框架,其灵感来源于自然机理受体功能.
- 开发和评估生物模拟刺激政策,以恢复自然感官信息.
- 评估该框架在改善患者流动性和减少认知负载方面的有效性.
主要方法:
- 开发了一个机械受体的in-silico模型,以创建仿生刺激政策.
- 实验评估了对猫的机械触摸和线性神经调节的仿生刺激.
- 在人类临床试验 (NCT03350061) 的生物体设备中实现了仿生神经刺激框架.
主要成果:
- 生物仿真神经调节成功地传递了神经反应到猫的背部根结节和脊髓.
- 通过仿生刺激诱导的神经动态与自然发生的模式非常相似.
- 临床试验表明,与传统方法相比,移动性显著改善,精神努力减少.
结论:
- 开发的生物模拟神经刺激框架为感官恢复提供了一种自然而有效的方法.
- 这种由神经科学驱动的技术有可能成为未来辅助神经技术的模型.
- 生物模拟刺激在为神经障碍患者创造直观感官体验方面取得了重大进展.
相关概念视频
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
Tactile and Chemical Senses
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...


