在对抑郁症进行有效的深度大脑刺激后,睡眠的皮层特征发生变化
Joram J van Rheede1, Sankaraleengam Alagapan2, Timothy J Denison3,4
1MRC Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. joram.vanrheede@bndu.ox.ac.uk.
Translational psychiatry
|February 20, 2024
概括
对治疗耐药性抑郁症 (TRD) 的深度大脑刺激 (DBS) 提高了睡眠时间和睡眠密度. 这项研究研究了TRD患者在下带皮层DBS之后的长期电生理学睡眠变化.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 脑下环皮层 (SCC) 的深度大脑刺激 (DBS) 是治疗耐药性抑郁症 (TRD) 的实验性疗法.
- 慢性SCC DBS在清醒期间改变了电生理学动力学,但它对睡眠相关的大脑活动的影响在很大程度上是未知的.
- 了解DBS对睡眠的影响至关重要,因为抑郁症,睡眠障碍和DBS-睡眠-循环节相互作用的新兴研究之间存在强烈联系.
研究的目的:
- 描述与TRD的DBS治疗相关的睡眠电生理学标记的长期变化.
- 调查慢性SCC DBS对慢波活动 (SWA) 和睡眠螺旋的影响.
主要方法:
- 在9名对DBS有反应的TRD患者中,从SCC记录的局部现场潜力 (LFP) 的分析.
- 在24周治疗有效的SCC DBS之前和之后,电生理睡眠特征 (SWA和睡眠) 的比较.
- 评估SWA功率,定时,稳定性和睡眠密度.
主要成果:
- 慢波活动 (SWA) 功率在半球之间高度相关,表明全球睡眠状态.
- 慢性SCC DBS导致早期发病,并在夜间出现更突出的SWA峰值.
- 观察到睡眠的密度增加,而SWA功率和稳定性保持不变.
结论:
- 这项研究提供了第一份关于SCC在接受DBS的TRD患者中长期电生理学睡眠标志物的报告.
- 临床有效的SCC DBS治疗与非快速眼动 (NREM) 睡眠的早期发作和睡眠螺旋活动的增加有关.
- 需要进一步的研究来确定长期DBS和睡眠的潜在神经机制之间的因果关系.
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