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Updated: Jul 2, 2025

Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate
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对物理化学和结构特性进行比较的研究表明,BGL-ASP与参考胰岛素阿斯巴尔特之间存在很高的生物相似性

Nikhil S Ghade1, Damodar K Thappa2, Jeseena Lona2

  • 1BioGenomics Limited, Thane, Maharashtra, 400610, India. nikhil.ghade@biogenomics.co.in.

Scientific reports
|February 20, 2024
PubMed
概括

生物类似胰岛素阿斯巴特 (BGL-ASP) 在结构,纯度和功能方面与参考产品具有很高的相似性. 临床试验证实了其可比的安全性和有效性,为糖尿病治疗提供了经济的替代方案.

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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