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采矿Cepharanthine类似物和Stephania的基因组加速抗冠状病毒药物发现

Liang Leng¹, Zhichao Xu², Bixia Hong³

¹Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Nature communications

|February 20, 2024

概括

研究人员确定了七种具有针对冠状病毒的广泛抗病毒活性,包括SARS-CoV-2的cepharanthine类似物. 这一发现加速了针对各种病毒感染的新抗病毒药物的开发.

科学领域:

自然产品化学自然产品化学
病毒学病毒学
基因组学就是基因组学.

背景情况:

斯蒂法尼亚的植物性化合物Cepharanthine对冠状病毒具有已知的抗病毒特性.
对抗新兴和重新出现的冠状病毒的广泛抗病毒药物的迫切需要,需要进一步研究基于天然产品的疗法.

研究的目的:

组装斯蒂芬尼亚基因组并阐明头氨酸生物合成途径.
识别和评估新型塞法兰类型的抗病毒潜力,以对抗一系列冠状病毒.

主要方法:

三种Stephania物种 (S. japonica,S. yunnanensis,S. cepharantha) 的基因组组合.
生物合成基因挖掘和代谢学分析以确定途径化合物.
在体外评估针对各种冠状病毒的已识别化合物,包括SARS-CoV-2,GX_P2V,SADS-CoV和PEDV.

主要成果:

在Stephania物种中实现了近端粒到端粒和染色体水平的基因组组合.
确定了七种表胺类同类物,显示出广泛的抗病毒活性.
证实了相关品种Nelumbo和Thalictrum的抗病毒潜力,用于制造西法兰丁模拟物.

结论:

这项研究为了解头氨酸生物合成及其类似物提供了基础.
已识别的化合物显示出针对冠状病毒的广泛抗病毒药物发现的重大前景.
这项研究可以加速开发新型冠状病毒感染治疗策略.

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