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28个NICU参与了针对早期发作的败血症的质量改善合作,使用抗生素
Kurlen S E Payton1,2, Mihoko V Bennett3,4, Joseph Schulman5
1Department of Pediatrics, Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. kurlen.payton@cshs.org.
概括
新生儿重症监护室 (NICU) 的抗生素使用量通过早期发作的败血症 (EOS) 管理质量改善协作减少了15.3%. 这一举措成功地降低了抗生素利用率,而没有增加感染率.
科学领域:
- 新生儿医学 新生儿医学
- 传染病管理 传染病管理
- 提高质量 提高科学 提高质量
背景情况:
- 过度使用抗生素是新生儿重症监护室 (NICU) 的一个重要问题.
- 针对早期发作的败血症 (EOS) 管理是抗生素管理的关键策略.
- 新生儿重症监护室需要有效的干预措施来优化抗生素的使用.
研究的目的:
- 为了降低新生儿重症监护室 (NICU) 的抗生素利用率 (AUR).
- 实施一个全州范围的,多中心的质量改进协作,专注于EOS管理.
- 在脆弱的新生儿群体中安全降低抗生素暴露.
主要方法:
- 一个全州的多中心抗生素管理质量改善协作成立.
- 28个NICU参与了合作倡议.
- 主要目标是实现每月平均抗生素利用率 (AUR) 的25%降低.
主要成果:
- 在抗生素利用率 (AUR) 中,总体减少了15.3% (p < 0.001).
- 在参与的NICU中观察到改善的显著变化.
- 没有发现早期发作的败血症 (EOS) 或医院感染率的增加.
结论:
- 参与NICU抗生素管理协作有效减少了总体抗生素使用.
- 干预表明,针对EOS管理可以导致抗生素利用率大幅降低.
- 这些发现支持实施类似的倡议,以维持在NICU中改善抗生素管理.
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