在非传染性眼膜炎患者的眼睛中,阿达利穆马布对胸膜厚度和胸膜血管度指数的影响,使用增强深度成像光学连贯断层扫描
Cem Evereklioglu1, Elif Er Arslantas2, Hidayet Sener2
1Department of Ophthalmology, Division of Uvea-Behçet Unit, Erciyes University Medical Faculty, Kayseri, Türkiye. cemevereklioglu@gmail.com.
Eye (London, England)
|February 20, 2024
概括
在非传染性脑膜炎 (NIU) 眼睛中,阿达利穆马布 (ADA) 并没有改变胸腔血管性指数 (CVI). 在NIU和非阴眼中降低CVI表明系统性炎症会影响胆道血管.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 非传染性脑膜炎 (NIU) 涉及眼部炎症.
- 系统性炎症可能会影响胆道血管系统.
- 阿达利穆马布 (ADA) 是一种用于治疗NIU的抗瘤缩因子 (TNF) 生物药物.
研究的目的:
- 评估阿达利穆马布 (ADA) 对非传染性眼膜炎 (NIU) 眼睛的胸膜厚度 (ChT) 和胸膜血管度指数 (CVI) 的影响.
主要方法:
- 增强的深度成像光学连贯性断层扫描 (EDI-OCT) 用于测量ChT和分析NIU眼睛,非阴道眼 (NU) 眼睛和健康对照中的胆道血管.
- CVI是用光面积 (LA) 与总胆道面积 (TCA) 的比率来计算的.
- ADA治疗用于耐火NIU的成人和儿科患者.
主要成果:
- 胸膜厚度 (ChT) 在所有组中都是相似的.
- 与健康对照组相比,NIU眼 (0.63 ± 0.007) 和NU眼 (0.66 ± 0.006) 的冠状血管度指数 (CVI) 在NIU眼 (0.63 ± 0.007) 和NU眼 (0.66 ± 0.006) 中明显较低 (0.70 ± 0.007).
- 在研究期间,Adalimumab (ADA) 治疗没有导致NIU眼睛的CVI发生显著变化.
结论:
- 在NIU和NU眼睛中减少的CVI表明,系统性炎症会影响胆道血管和输液,无论眼睛是否受到影响.
- 冠状血管性指数 (CVI) 可能成为监测NIU眼部干扰和疾病进展的新工具.
- 在NIU中,CVI似乎不是可靠的生物标志物来监测阿达利穆马布 (ADA) 治疗疗效.
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