右前额带状皮质调解产前并发症对年轻人内化行为的影响
Eleonora Maggioni1, Alessandro Pigoni2,3, Elisa Fontana4
1Department of Electronics Information and Bioengineering, Politecnico di Milano, Milano, Italy.
Molecular psychiatry
|February 21, 2024
概括
产前并发症与脑前部灰质体积 (GMV) 的减少以及儿童内行为增加有关. 额头的GMV调解了这种关联,这表明了发展内化症状的途径.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 产科并发症是精神疾病的已知危险因素.
- 童年和青春期是大脑和行为发展的关键时期.
- 需要明确产科并发症,行为和大脑结构之间的联系.
研究的目的:
- 调查产前/产周并发症,行为问题和儿童和青少年大脑体积之间的关联.
- 探索大脑结构在这种关系中的调解作用.
主要方法:
- 82名患有情绪行为问题的儿童/青少年接受了临床和3T脑部MRI.
- 使用儿童行为检查清单/6-18 (CBCL/6-18) 收集的行为数据.
- 统计分析包括一般化的线性模型和调解模型.
主要成果:
- 产前并发症与更高的CBCL/6-18撤回得分有关.
- 观察到右上额头回形和前带皮层的灰质体积 (GMV) 减少.
- 调解分析显示,正面GMV调解了产前并发症和隐蔽行为之间的联系.
结论:
- 产科并发症在改变大脑结构和行为方面发挥着重要作用.
- 额头的GMV可能会调解产前并发症和内化症状之间的关系.
- 研究结果表明,在有风险的年轻人中,预防性干预的潜在目标是.
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