间歇性禁食促进了老年脂肪组织中免疫衰老表型的再生
Kafi N Ealey1, Jacques Togo1, Ju Hee Lee1,2
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
GeroScience
|February 21, 2024
概括
间歇性禁食 (IF) 通过减少衰老细胞和增加有益的乙氨基酸细胞,使衰老的白色脂肪组织 (WAT) 恢复青春. 这种饮食方法可以对抗与年龄相关的代谢功能障碍.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 衰老的白色脂肪组织 (WAT) 具有衰老的脂肪干细胞和原始细胞 (ASPC) 和免疫失调的特征,导致代谢疾病.
- 消除衰老的ASPC可以改善健康状况,间歇性禁食 (IF) 在管理代谢功能障碍方面表现有前途.
- 关于IF对WATASPC和免疫细胞老化特异性变化的影响的研究有限.
研究的目的:
- 研究间歇性禁食 (IF) 对白色脂肪组织 (WAT) 中老化特异性的细胞和免疫变化的影响.
- 确定IF能否减轻与年龄相关的脂肪功能障碍,并改善老年小鼠的代谢健康.
主要方法:
- 用间歇性禁食 (IF) 方案治疗18-20个月大的小鼠.
- 评估脂肪干细胞和原生细胞 (ASPC) 中的衰老表型.
- 在WAT.中评估脂肪生成潜力和免疫细胞种群 (特别是乙酸性细胞).
主要成果:
- 从老年小鼠的ASPC中,IF降低了老化表型.
- IF治疗恢复了老年ASPCs的脂肪生成潜力.
- 在老年小鼠中,IF增加了脂肪乙氨基基细胞的数量,与改善WAT恒温和免疫健康有关.
结论:
- 间歇性禁食 (IF) 改善了白色脂肪组织 (WAT) 干细胞中因衰老引起的衰老.
- 通过增加异osinophils,IF促进了WAT内的更健康的免疫微环境.
- IF是一种潜在的生活方式干预,可以抵消与年龄相关的WAT功能障碍和代谢疾病.
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