在患有自闭症谱系障碍并发症ADHD的儿童中改变了内在大脑自发活动
Xinzhou Tang1,2, Zenghui Ma1, Kat SiuChing1
1National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Journal of attention disorders
|February 21, 2024
概括
患有自闭症谱系障碍的孩子加上ADHD显示出不同的大脑活动模式. 这项研究增强了对ASD和ADHD同时发生的神经基础的理解.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 自闭症谱系障碍 (ASD) 和注意力缺陷/多动性障碍 (ADHD) 是常见的神经发育状况.
- 自闭症和多动症的同时发生很常见,这表明共享或相互作用的神经机制.
- 了解不同且重叠的神经支柱对于诊断和治疗至关重要.
研究的目的:
- 与典型发育的儿童相比,研究ASD,ADHD和ASD+ADHD并发症儿童的区域和全球大脑功能差异.
- 识别与每个疾病相关的特定神经标记物及其共同发生.
- 阐明在ASD和ADHD复杂相互作用的基础上的神经机制.
主要方法:
- 利用低频波动幅度 (ALFF) 来评估区域大脑功能.
- 分析了ALFF确定地区的内在功能连接 (iFC).
- 采用了包括ANCOVA和高斯随机场 (GRF) 理论在内的统计分析来进行群组比较.
主要成果:
- 与典型发育 (TD) 儿童相比,ASD+ADHD组在左中额头 (MFG.L) 中呈现出增加的ALFF.
- 与ASD+ADHD和TD组相比,ASD组在某些区域显示出减少的全球大脑连接.
- 在ASD,ADHD,ASD+ADHD和TD组中观察到不同的大脑功能模式.
结论:
- 这项研究提供了关于神经特征的见解,使ASD,ADHD和它们的共同发生区分开来.
- 这些发现突出了额叶在ASD+ADHD并发症病理生理学的作用.
- 这项研究有助于更好地了解神经发育障碍的神经生物学.
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