相关实验视频
Updated: Jul 2, 2025
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
10.9K
miR-142-3p/5p在癌症中的作用:从表观遗传调节到免疫调节
Parisa Zareifar1, Hani Moslem Ahmed2, Pouya Ghaderi3
1Golestan University of Medical Science, Gorgan, Golestan, Iran.
Cell biochemistry and function
|February 21, 2024
概括
微RNAs,特别是miR-142-3p/5p,是癌症的关键调节者,作为瘤基因或瘤抑制剂. 这篇评论详细介绍了它们在基因调节,免疫调节和治疗潜力的作用.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 微RNAs (miRNAs) 是癌症病理生物学中基因表达的关键调节者.
- miR-142-3p/5p被认为是各种恶性瘤的重要调节剂.
- 新出现的证据强调miR-142-3p/5p作为瘤基因或瘤抑制剂的双重作用.
研究的目的:
- 综合审查miR-142-3p/5p在癌症中的多方面的作用.
- 总结其在基因调节,表观遗传修饰和信号通路中的功能.
- 探索其免疫调节效应和瘤逃逸中的含义.
主要方法:
- 关于癌症中miR-142-3p/5p的当前研究的文献综述.
- 对调查miRNA针对表观遗传因素和信号通路的研究进行分析.
- 对miR-142-3p/5p的免疫调节功能的研究进行了审查.
主要成果:
- miR-142-3p/5p通过准表观遗传因素和与癌症相关的途径来调节广泛的下游基因.
- 它在免疫调节中发挥着关键作用,影响免疫抑制和瘤免疫逃避.
- 携带miR-142-3p/5p的外基因组参与细胞间通信,影响癌细胞的行为.
结论:
- miR-142-3p/5p在癌症中表现出复杂的功能,同时作为瘤基因和瘤抑制剂.
- 它的免疫调节特性为癌症免疫学和治疗策略提供了洞察力.
- miR-142-3p/5p具有在瘤学中的诊断和治疗应用的前景.
相关概念视频
01:46Epigenetic Regulation
31.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.1K
01:22MicroRNAs
21.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.3K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:06Induced Pluripotent Stem Cells
4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.1K