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在外听通道状细胞癌中EGFR和p16的表达

Yasuyuki Kajimoto¹, Hirotaka Shinomiya¹, Natsumi Uehara¹

¹Department of Otolaryngology-Head and Neck Surgery, Kobe University Hospital and Graduate School of Medicine, Kobe, Japan.

The Kobe journal of medical sciences

|February 21, 2024

概括

皮表皮生长因子受体 (EGFR) 和p16表达在外部听道状细胞癌 (EACSCC) 可能预测患者的结果. 负EGFR表达与生存相关,p16阳性表明在先进的EACSCC中预后更好.

科学领域:

在瘤学瘤学.
耳鼻喉科耳鼻喉科耳鼻喉科
癌症生物标志物癌症生物标志物

背景情况:

外耳道状细胞癌 (EACSCC) 是罕见的,关键生物标志物如表皮生长因子受体 (EGFR) 和p16的预后意义尚不清楚.
了解这些标志物可以帮助预测治疗反应和患者的结果.

研究的目的:

在EACSCC中调查EGFR和p16的表达水平.
评估EGFR和p16表达对EACSCC患者瘤结果的影响.

主要方法:

在1995年至2018年期间治疗的71名EACSCC患者的回顾性分析.
对EGFR和p16表达的免疫组织化学评估.
统计分析以将标记物表达与瘤结局相关联.

主要成果:

在87%的患者中观察到高EGFR表达.
在74.7%的患者中,p16表达是阳性的 (32.4%强,42.3%弱).
所有经过手术治疗的EGFR阴性表达的患者仍然没有疾病;积极的p16表达与晚期T3和T4a EACSCC中更好的预后相关.

结论:

EGFR和p16表达在预测高级EACSCC的瘤结果方面具有临床意义.
这些生物标志物可能有助于EACSCC风险分层和个性化治疗策略.

关键词:

欧洲农业基金会 (EGFR) 是一个.耳癌是一种耳癌.科比分类科比分类时间骨的骨.p16 p16 在这个问题上.

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