在处理情绪刺激期间,酒精对前-桃体功能连接的影响的性别差异
Benjamin S McKenna1,2, Robert M Anthenelli1, Marc A Schuckit1
1Department of Psychiatry, University of California, San Diego, Health Sciences, La Jolla, California, USA.
Alcohol, clinical & experimental research
|February 21, 2024
概括
酒精对男性和女性的大脑连接有不同的影响. 当女性中毒时,桃体功能连接性增加,可能会增强情绪处理.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 成研究 研究成研究
背景情况:
- 杏仁体功能的个体差异与生物性和情绪处理有关.
- 以前使用功能磁共振成像 (fMRI) 的研究集中在低级别的杏仁体反应上.
- 这项研究调查了酒精和性对杏仁体和其他大脑区域之间的功能连接的影响.
研究的目的:
- 检查酒精消费如何影响前边缘电路中的功能连接.
- 为了确定生物性别是否影响酒精对处理情绪面部表情的影响.
- 通过分析功能连接模式来扩展先前的fMRI发现.
主要方法:
- 来自双盲,安慰剂控制,主体内,交叉研究的数据的二次分析.
- 参与了108名18-25岁的参与者 (54个性别匹配对),没有酒精使用障碍.
- 使用功能磁共振成像 (fMRI) 和安慰剂或酒精后的心理生理相互作用分析.
主要成果:
- 在消极面部情绪处理方面发现了显著的酒精与性别相互作用.
- 醉酒的男性显示杏仁体连接性下降;醉酒的女性显示连接性增加.
- 观察到胰岛和前额回形连接的性别差异,酒精影响了两性上级前额回形连接.
结论:
- 酒精对参与情绪处理的杏仁体功能电路的影响取决于性别.
- 在中度饮酒后,女性表现出比男性更大的功能连接性.
- 这表明女性可能在醉酒时增强了情感刺激处理能力.
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