在自发早产妇女中与心血管疾病相关的生物标志物:一个病例对照研究
Elin Täufer Cederlöf1, Susanne Lager2, Anders Larsson3
1Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Acta obstetricia et gynecologica Scandinavica
|February 21, 2024
概括
自发早产妇女在怀孕期间和十年后表现出纤维素水平升高. 这可能表明早产和心血管疾病风险之间有共同的路径.
科学领域:
- 心血管疾病的研究研究.
- 生殖健康 生殖健康
- 发现生物标志物的发现.
背景情况:
- 自发早产 (SPB) 与晚年心血管疾病 (CVD) 风险的增加有关.
- 怀疑潜在的共享病理生理机制,但尚未完全理解.
- 蛋白质生物标志物在识别这些联系中的作用尚不清楚.
研究的目的:
- 调查与心血管疾病相关的蛋白质生物标志物是否可以将SPB妇女与对照区分开来.
- 在怀孕期间和长期随访时分析生物标志物.
主要方法:
- 从怀孕中期的SPB病例 (N=13) 和对照组 (N=6) 的血样本使用质谱分析.
- 在怀孕4-15年后,对100例SPB病例和100个匹配的对照进行了验证队列的跟踪.
- 在两个时间点测量了选定的生物标志物和脂质资料的度.
主要成果:
- 查发现了怀孕期间纤维素,素-5,补充C5,XII因子,血卡利克林,阿波利波蛋白M和维生素D结合蛋白的差异.
- 在随访时,SPB病例中纤维素 (p=0.02) 和甘油三 (p=0.03) 在SPB病例中略高于对照组.
- 65名参与者 (35个病例,30个对照组) 在平均11.8年后完成了随访.
结论:
- 患有SPB的女性在怀孕期间和大约十年后呈现出轻微升高的纤维素水平.
- 在跟踪期间,在有史以来SPB的女性中观察到高甘油度.
- 这些发现表明SPB和CVD之间可能存在共同的病理生理联系,尽管需要进一步的研究来澄清它们的相关性.
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