腰椎间盘患者的改变自发大脑活动:ALE对神经成像数据的元分析的见解
Zhiqiang Qiu1, Xiangkai Zhong1, Qiming Yang1
1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Frontiers in neuroscience
|February 21, 2024
概括
这一元分析显示,腰椎间盘 (LDH) 患者的自发大脑活动发生变化,特别是在右中额头回形和左前带状皮层. 需要进一步的研究来确认对LDH疼痛的特异性.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 疼痛医学 医学 疼痛医学
背景情况:
- 腰椎间盘 (LDH) 是腰部疼痛的一个常见原因.
- 之前对LDH患者大脑活动的神经成像研究已经 yielded矛盾的发现.
- 了解大脑活动的变化对于理解LDH相关的疼痛机制至关重要.
研究的目的:
- 调查腰椎间盘 (LDH) 患者的自发大脑活动变化.
- 调和现有文献中关于LDH脑活动的相互矛盾的结果.
- 为了提高对LDH相关疼痛的神经生物学基础的理解.
主要方法:
- 在PubMed,Web of Science,Embase,CNKI,SinoMed和Wanfang数据库中进行了系统的文献搜索.
- 包括使用区域同质性 (ReHo) 和低频波动幅度 (ALFF/fALFF) 分析的研究.
- 使用激活概率估计 (ALE) 分析来确定一致的大脑区域变化.
主要成果:
- 分析了11项涉及269名LDH患者和277名健康对照者的研究.
- 与HC患者相比,LDH患者在右中额头 (MFG) 和左前带状皮层 (ACC) 的自发大脑活动增加.
- 观察到左上额头 (SFG) 的活性下降,与ALFF/fALFF和ReHo数据的结合.
结论:
- 在LDH患者中,元分析确定了右MFG,左ACC,右前脑叶和左SFG的显著自发大脑活动变化.
- 这些发现对LDH的特异性需要进一步调查,可能与其他慢性疼痛疾病进行比较.
- 未来的研究应该考虑按疼痛侧进行分组,以澄清LDH相关疼痛中的横向化效应.
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