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Updated: Jun 20, 2026

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
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稳定纤维细胞生长因子21的计算机辅助工程

Gabin de La Bourdonnaye1,2, Tereza Ghazalova2, Petr Fojtik3

  • 1Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Computational and structural biotechnology journal
|February 21, 2024
PubMed
概括

纤维细胞生长因子21 (FGF21) 变体被设计为增强稳定性和在代谢疾病中的治疗潜力. 计算机辅助设计提高了温度稳定性,而不会影响基于细胞的测定中的有效性.

关键词:
纤维细胞生长因子21 21蛋白质工程是一种蛋白质工程.蛋白质稳定 蛋白质稳定

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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