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Updated: Jul 2, 2025

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神经发育和神经精神疾病中的神经激素功能障碍:通过iPSC和动物模型进行基于PRIMSA的系统审查

Dan Shan1,2, Yuming Song3, Yanyi Zhang4

  • 1Department of Biobehavioral Sciences, Columbia University, New York, NY, United States.

Frontiers in behavioral neuroscience
|February 21, 2024
PubMed
概括

神经素蛋白功能障碍与自闭症谱系障碍 (ASD) 和精神分裂症等神经发育障碍密切相关. 研究强调神经毒素.

关键词:
动物模型动物模型疾病建模 疾病建模人类诱导的多能干细胞干细胞.这些神经素 (neurexins)神经精神疾病的神经精神疾病.

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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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