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脑癌的定量动态对比增强磁共振成像:不同建模方法的系统比较

Marte Kåstad Høiskar¹, Oddbjørn Sæther², Mirjam Delange Alsaker³

¹Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.

Physics and imaging in radiation oncology

|February 21, 2024

概括

对头癌 (HNC) 进行精确的药理动力学建模动态对比增强MRI需要个别的动脉输入功能. DCE-MRI参数与T阶段和HPV状态相关,影响预后潜力.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

动态对比增强型MRI (DCE-MRI) 通过表征组织微血管结构,为头癌 (HNC) 放射治疗提供预后和预测见解.
在DCE-MRI协议中缺乏标准化,阻碍了研究比较和临床整合.

研究的目的:

在DCE-MRI中调查人口动脉输入函数 (AIF) 对HNC的准确性和稳定性.
分析药理动力学参数之间的相关性及其与T阶段和人类乳头瘤病毒 (HPV) 状态的关联.

主要方法:

从44名HNC患者获得的DCE-MRI数据.
使用六种不同的方法计算了人口AIF,并使用Tofts (TM),扩展TM (ETM) 和Brix模型 (BM) 分析了DCE-MRI,以及曲线下的面积 (AUC).
采用了类内相关性,对应性相关性,皮尔森相关性和惠特尼-曼U测试来评估稳定性,准确性和关联性.

主要成果:

人口AIF是强大的,但与个人AIF不同.
在各种模型和淋巴结 (ABrix,AUCs) 的各种药理动力学参数 (Ktrans,ve,Kep) 之间观察到显著的相关性.
Kep (TM) 随着T阶段的增加而下降,在HPV阴性病变中更强烈的关联.

结论:

对于HNC中精确的DCE-MRI药理动力学建模,个人AIF是首选的.
DCE-MRI参数及其相关性受病变类型,HPV状态和T阶段的影响,影响临床效用.

关键词:

动脉输入功能的动脉输入功能.动态对比增强MRI的动态对比增强.头癌是头部和部的癌症.药物动力学建模药物动力学建模 T 阶段化 T 阶段化

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Magnetic Resonance Imaging

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