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年轻女性乳腺癌:有什么不同? 一个单一中心的回顾性队列研究

Omalkhair Abulkhair¹, Ahmad Omair², Dorothy Makanjuola³

¹Oncology Department, Suliman Alhabib Hospital, Riyadh, Saudi Arabia.

Clinical Medicine Insights. Oncology

|February 21, 2024

概括

被诊断为乳腺癌 (BC) 的年轻女性面临更高的复发率,但整体存活率与老年患者相似. 然而,年轻女性的光线A亚型BC体验较差的结果,需要进一步调查.

科学领域:

在瘤学瘤学.
临床研究临床研究
流行病学流行病学

背景情况:

乳腺癌 (BC) 在全球范围内不成比例地影响女性,年轻女性 (<40岁) 往往呈现出较差的预后.
关于这种年轻人群的临床病理特征和长期结果的数据有限.

研究的目的:

为了比较40岁或更年轻的乳腺癌患者的临床病理特征和长期疾病结果,与老年患者进行比较.
确定导致年轻和老年乳腺癌队列生存差异的因素.

主要方法:

在10年内对695名乳腺癌患者进行了回顾性队列研究.
对40岁以下和40岁以上患者的临床病理学特征和结果进行比较.
统计分析包括考克斯回归和卡普兰-梅尔曲线的整体存活 (OS).

主要成果:

与老年患者相比,年轻的患者表现出较少的雌激素受体 (ER) 和孕激素受体 (PR) 阳性.
虽然整体存活率没有显著差异,但年轻患者的复发率 (12.6%与6.3%) 和疾病进展率 (29.4%与18.2%) 较高.
较年轻的Luminal A分子亚型患者的结果明显较差.

结论:

与老年患者相比,被诊断为40岁以下的乳腺癌患者的整体存活率并没有明显下降.
年轻女性患有A型乳腺癌呈现较差的生存结果.
进一步的研究对于阐明乳腺癌中基于年龄的结果差异背后的机制至关重要.

关键词:

乳腺癌乳腺癌乳腺癌临床病理学特征临床病理学特征长期的结果是长期的结果.总体存活率总体存活率

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