肺移植后发生初级移植功能障碍的捐赠者和接受者风险因素
J Asher Jenkins1, Ricardo Verdiner2, Ashraf Omar3
1Department of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, AZ, United States.
Frontiers in immunology
|February 21, 2024
概括
肺移植后的初级移植功能障碍 (PGD) 存在重大风险. 这篇综述涵盖了PGD文献,缓解策略和最近的进展,如ex-vivo肺 perfusion.
科学领域:
- 移植医学 移植医学
- 免疫学 免疫学 免疫学
- 肺部医学 肺部医学
背景情况:
- 主要移植功能障碍 (PGD) 是影响肺移植结果的关键并发症.
- 已识别的PGD风险因素包括捐赠者,接受者和技术因素.
研究的目的:
- 提供关于肺移植中PGD的当前文献的全面审查.
- 讨论PGD缓解策略和未来的研究方向.
主要方法:
- 文献综述专注于肺移植中的PGD.
- 包括最近的进展,如ex-vivo肺 perfusion和正常热区域 perfusion.
- 考虑2016年后的文献 ISHLT共识和COVID-19大流行的影响.
主要成果:
- 在肺移植中,PGD仍然是一个重大挑战.
- 最近的进展为改善PGD管理提供了潜力.
- 由于COVID-19的流行,已经影响了移植实践和PGD的考虑.
结论:
- 有效的PGD管理对于改善短期和长期肺移植存活率至关重要.
- 新兴技术和最新的文献为PGD预防和治疗提供了新的见解.
- 持续的研究对于进一步减轻PGD和优化患者的治疗结果至关重要.
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